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KMID : 0545120160260020309
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 2 p.309 ~ p.314
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Apoptotic Effects of Cordycepin Through the Extrinsic Pathway and p38 MAPK Activation in Human Glioblastoma U87MG Cells
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Baik Ji-Sue
Mun Seo-Won
Kim Kyoung-Sook
Park Shin-Ji
Yoon Hyun-Kyoung
Kim Dong-Hyun
Park Min-Kyu
Kim Cheorl-Ho
Lee Young-Choon
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Abstract
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We first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in U87MG cells with wild-type p53, but not in T98G cells with mutant-type p53. Western blot data revealed that the levels of procaspase-8, -3, and Bcl-2 were downregulated in cordycepintreated U87MG cells, whereas the levels of Fas, FasL, Bak, cleaved caspase-3, -8, and cleaved PARP were upregulated, indicating that cordycepin induces apoptosis by activating the death receptor-mediated pathway in U87MG cells. Cordycepin-induced apoptosis could be suppressed by only SB203580, a p38 MAPK-specific inhibitor. These results suggest that cordycepin triggered apoptosis in U87MG cells through p38 MAPK activation and inhibition of the Akt survival pathway.
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KEYWORD
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Cordycepin, apoptosis, extrinsic pathway, U87MG cell, p38 MAPK
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